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Posted by Jim Till on May 09, 1999 at 10:38:47:
In Reply to: Interesting paper (about an insulin mimetic) posted by Jim Till on May 09, 1999 at 10:30:39:
If one believes that regulatory networks involve a lot of redundancy, then
longer-term side effects might be expected. If one also believes that
regulatory networks in mice and humans may differ, at least
quantitatively, then there's also the possibility of severe longer-term
side effects in humans that are not apparent in mice. Another paper by
Risch et al (Medline UI: 93356164), about a mouse model of diabetes, is of
some interest from this point of view?
For the Medline abstract of the paper by Risch et al, please see the link attached below.